Advances in the Study of Cigar Smoke-Mediated Lung and Intestinal Injuries, Gut Microbiota Alterations, and Underlying Mechanisms_Vol. 2 No. 3 (JLSA 2025)_Journal of Life Sciences and Agriculture (ISSN: 3005-5709)

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Advances in the Study of Cigar Smoke-Mediated Lung and Intestinal Injuries, Gut Microbiota Alterations, and Underlying Mechanisms

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DOI: https://doi.org/10.62517/jlsa.202507306

Author(s)

Lin Li1, Jie Gao1, Chunhuan Yuan1, Yantiao Yang1, Yunhan Huang1, Wan Yang1, Yuan He2,*

Affiliation(s)

1College of Life Sciences, Zhengzhou Normal University, Zhengzhou, Henan, China 2Cigar Innovation Center, College of Tobacco Science and Engineering, Zhengzhou University of Light Industry, Zhengzhou, Henan, China * Corresponding Author

Abstract

This review discusses the mechanisms underlying cigar smoke-induced lung and intestinal injuries and associated alterations in gut microbiota. Cigar smoke, as a harmful environmental factor, exerts multifaceted effects on human health. In terms of pulmonary damage, harmful components within the smoke can trigger inflammation, oxidative stress responses, and lead to decline in lung function, thereby elevating the risk of respiratory diseases such as lung cancer. Regarding intestinal health, cigar smoke may affect intestinal function through systemic circulation pathways, resulting in mucosal damage and altered permeability. Moreover, cigar smoke significantly modifies the composition and structure of the gut microbiota. Evidence suggests that changes in gut microbiota could further exacerbate lung and intestinal injuries, forming a vicious cycle. The underlying mechanisms may involve immune response dysregulation and metabolic disturbances. This review provides an in-depth analysis of the pathways through which cigar smoke mediates pulmonary and intestinal damage, as well as alterations in gut microbiota, offering new insights and strategies for the prevention and treatment of related diseases.

Keywords

Cigar Smoke; Lung Injury; Intestinal Injury; Gut Microbiota

References

[1] Yang, J., Luo, C., Li, D., et al. Advances in chemical constituents of cigars smoke. Acta Tabacaria Sinica, 2021, 27(4): 100-105. [2] Cheng, C., Han, C., Fang, Q., et al. Exploring the environmental influencing factors of lung cancer incidence based on geographically and temporally weighted regression model. Journal of Shandong University (Health Sciences), 2023, 61(4): 95–102. [3] Huo, X., Geng, J.Progress in the relationship between intestinal flora and its metabolites with cardiovascular diseases. Tianjin Medical Journal, 2020, 48(5):460-464. [4] Han, H., Peng, G., Meister, M., et al. Electronic cigarette exposure enhances lung inflammatory and fibrotic responses in COPD mice. Frontiers in Pharmacology, 2021, 12: 726586. [5] Kang, D., Gao, Y., Ma, J., et al. Establishment and evaluation of risk model of idiopathic pulmonary interstitial fibrosis complicated with emphysema. Chinese Journal of Difficult and Complicatied Cases, 2022, 21(12): 1236-1241. [6] Hua YF, Yang CH, Chen H. The effects of cigarette smoke extract on the growth of rat pulmonary fibroblasts. Health Protection and Promotion, 2023; 23(24): 1850-1853. [7] Zeng, X., Zhou, Q., Tong, J. Role of cigarette smoke in the development of severe pneumonia and related research progress. Basic and Clinical Medicine, 2023, 43(7): 1157. [8] Peng J. Exploring the role of epigenetic modification in cigarette smoke–induced airway inflammation in mice by genome-wide DNA methylation capture sequencing. Sichuan University, 2023. [9] Xie Y, Mei XX, Tao LY, et al. Mechanism of airway epithelial barrier injury in a mouse model of COPD induced by cigarette smoke exposure combined with Poly I:C. Chinese Journal of Pathophysiology, 2024; 40(07): 1222-1229. [10] Zhang ZY, Mei XX, Tao LY, et al. Mechanism of airway remolding in a mouse model of chronic obstructive pulmonary disease induced by cigarette smoke combined with Klebsiella pneumoniae. Acta Laboratorium Animalis Scientia Sinica, 2025; 33(05): 644-655. [11] Chen, Q., Zhang, G., He, T. Progress in the study of gut-lung axis microbiota and tuberculosis. South China Journal of Preventive Medicine, 2023, 49(8): 1005–1009. [12] Li, L., Yang, L. Research advances of microbial communities of lung and intestinal in asthma. Chinese Medical Herald, 2022, 19(17): 42–45. [13] Yan, J., Lyu, B., Cheng, X. Research progress on the regulation of immune system by gut microbiota in cardiovascular diseases. Journal of Clinical Cardiovascular(China), 2022, 38(8): 614–618. [14] Zhang, D., Liu, Y., Jiang, F., et al. Relationship between intestinal flora and childhood asthma from the perspective of relationship between lung and intestine. Chinese Journal of Microecology, 2023, 35(6): 730–735. [15] Li, C., Peng, M., Tan, Z .Progress in research of intestinal microbiota related short chain fatty acids. World Chinese Journal of Digestology, 2022, 30(13): 562–570. [16] Shu, Y., Hui, H., Tan, Z. Advances in correlation between short-chain fatty acids and diarrhea. Chinese Journal of Infection Control, 2022, 21(9): 937–943. [17] El-Sherkawi, T., Saeid, A. B., Yeung, S., et al. Therapeutic potential of 18-β-glycyrrhetinic acid-loaded PLGA nanoparticles in a cigarette smoke-induced in vitro COPD model. Pathology - Research and Practice, 2024, 263: 155629. [18] Zuo, J., Chen, J., Ming, W., et al. SB239063 Attenuates the Expression Level of MKP-1 Via Suppressing TNF-α and p38MAPKin Rats with Allergic Rhinitis Exposured to Cigarette Smoke. Progress in Modern Biomedicine, 2022, 22(24). [19] Sha, S., Dong, S., Yang, Y. Research Progress in Gut Microbiota and Metabolites Regulating Host Intestinal Immunity. Biotechnology Bulletin, 2023, 39(8): 126-136.