The Clinical Value of PET-CT in Searching for Primary Lesions of Malignances_Vol. 1 No. 3 (JMHS 2023)_Journal of Medicine and Health Science (ISSN: 2959-0639)

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The Clinical Value of PET-CT in Searching for Primary Lesions of Malignances

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DOI: https://doi.org/10.62517/jmhs.202305302

Author(s)

Wei Zhang, Yan Zhang, Minggang Huang, Huitong Liu, Bingqiang Xu*

Affiliation(s)

Shaanxi Provincial People's Hospital, Xi'an, Shaanxi, China *Corresponding Author.

Abstract

This paper is aimed to explore the clinical value of 18F-FDG PET-CT in searching for primary lesions of multiple metastatic malignances. Data of 35 patients with multiple metastatic malignances which the primary lesion was not clear, were retrospectively studied from January 2019 to April 2023 in our hospital. Systemic 18F-FDG PET-CT examination was performed for all the patients, and the follow-up data were analyzed and summarized. The positive rate of 18F-FDG PET-CT for primary malignant lesions was 74.29% (26/35), the specificity was 87.28%, the sensitivity was 85.43%, and the accuracy was 88.73%. The positive predictive value was 92.31% (24/26). 18F-FDG PET-CT showed a high detection rate of metastatic squamous cell carcinoma and metastatic adenocarcinoma, with 85.36% and 82.41% respectively. 18F-FDG PET-CT examination provides high clinical value in multiple searches of primary metastasis throughout the body.

Keywords

PET-CT; Primary Lesions; Malignances; Rate; Clinical Value

References

[1]DIAS AH, HANSEN AK, MUNK OL, et al. Normal values for 18F-FDG uptake in organs and tissues measured by dynamic whole body multiparametric FDG PET in 126 patients. EJNMMI Research, 2022, 12 (1): 15-28. [2]Ma JL, Li XY, Zhao SF, et al. Advances in diagnostic methods of clinical staging for gastric cancer. Journal of Shanghai Jiaotong University (Medical Science), 2021, 41 (06): 821-825. [3]Ge R, Zhao LX, Tian R, et al. The role of 18F-FDG PET-CT in the detection of primary lesions for patients with tumor metastasis. Journal of China Clinic Medical Imaging, 2012, 23 (10): 722-726. [4]PIETRZAK AK, KAMIERSKA J, MARSZAEK A, et al. Dual-time point PET/CT study protocol can improve the larynx cancer diagnosis. Reports of Practical Oncology and Radiotherapy, 2020, 25 (4): 533-538. [5]PANG L, BO X, WANG J, et al. Role of Dual-time point PET/CT in the primary diagnosis and staging of hilar cholangiocarcinoma. Abdominal Radiology, 2021, 46 (9): 4138-4147. [6]Gu PF, Deng JY, Liang H. Research advances in preoperative staging of gastric cancer. Chinese Journal of Clinical Oncology, 2019, 46 (1): 6-11. [7]Xu XX, Cheng J, Xu GW, et al. Value of dual-time-point 18F-fluorodeoxyglucose integrated positron emission and computed tomography in differentiation of malignant from benign gastrointestinal diseases. Chinese Journal of Oncology, 2012, 34 (5): 364-368. [8]Wang SJ, Wang J, Yang WD, et al. The diagnostic value vale of 18F-FDG PET-CT in detecting thyroid disease. Functional and Molecular Medical Imaging (Electronic Edition), 2013, 4 (2): 247-251. [9]Maric T, Mikhaylov G, Khodakivskyi P, et al. Bioluminescent-based imaging and quantification of glucose uptake in vivo. Nat Methods. 2019;16 (6):526-532. [10]Zheng R, Wu N, Li J, et al. Application of 18F-FDG PET/CT in patients with biopsy proven tumor metastases from unknown primary site. Journal of China Clinic Medical Imaging, 2008, 19 (3): 164-167. [11]Kwee TC, Kwe RM. Combined FDG-PET/CT for the detection of unknown primary tumors: systematic review and meta-analysis. Eur Radiol, 2009, 19 (3): 731-744. [12]Xu WN, Yu SP, Xin J. Clinical value of 18F-FDG positron emission tomography in the detection of incidental high uptake of gastrointestinal tract. Journal of Modern Oncology, 2013, 21 (10): 2337-2339. [13]Li YK, Li CF, Liu JF. Searching for the unknown primary lesion of hepatic metastatic carcinoma. Practical Journal of Medicine & Pharmacy, 2015, 32 (12): 1082-1088. [14]Wang G, Dang H, Yu P, et al. Multiparameter Analysis Using 18F-FDG PET/CT in the Differential Diagnosis of Pancreatic Cystic Neoplasms. Contrast Media Mol Imaging, 2021, 2021:6658644. [15]Xu JY, Zhang YJ, Hu SL, et al. The discrimination of (18) F-FDG PET/CT detection of incidental ileocecal fluorodeoxyglucose uptake. China Oncology, 2010, 20 (2): 125-129. [16]Liu XG, Yan Y, Feng SY, et al. Comparison of preoperative PET-CT and pathological analyses in diagnosis of pulmonary tumors. The Journal of Practical Medicine, 2016, 32 (12): 1938-1941. [17]Zhang J, Ren SH, Zhang YY, et al. The Diagnostic Value of 18F-FDG PET-CT for Lung Occupying Lesion. Chinese Computed Medical Imaging, 2015, 21 (3): 294-297. [18]Guo J, Xie HJ. Value of 18F-FDG PET/CT on Differential Dignosis of Breast Benign and Malignant Lesions. Sichuan Medical Journal, 2018, 39 (5): 590-592. [19]Li W, Fan W. Value of esophageal abnormal metabolism lesions of 18F-FDG PET-CT for the clinical diagnosis of esophageal malignancy. Chinese Journal of Medical Imaging Technology, 2009, 25 (5): 901-904.