Efficacy Study of Mongolian Medicine Danga-5 Tablets on a Mouse Model of Functional Dyspepsia

DOI: https://doi.org/10.62517/jmhs.202405310

Author(s)

Haobishalatu1,*, Chen Wang2, Bilige1

Affiliation(s)

1Inner Mongolia International Mongolian Hospital, Hohhot, Inner Mongolia, China 2Affiliated Hospital of Inner Mongolia University for Nationalities, Hohhot, Inner Mongolia, China *Corresponding Author.

Abstract

Functional dyspepsia (FD) is one of the most common functional gastrointestinal disorders. This study evaluates the efficacy of Mongolian Medicine Danga-5 Tablets on a mouse model of functional dyspepsia. First, an FD mouse model was established, and the efficacy of Danga-5 Tablets was assessed after 14 days of continuous intervention, comparing the results with the normal group, model group, and positive control group. Indicators such as general condition, body weight change, gastric emptying rate, and small intestine transit rate were used to observe the effects and efficacy of the medicine on the mouse model of functional dyspepsia. The experimental results showed that Danga-5 Tablets significantly improved the general condition of the model group, as well as increased food intake, water intake, small intestine transit rate, gastric emptying rate, and body weight. Danga-5 Tablets have a regulatory effect on gastrointestinal dysfunction in the mouse model of functional dyspepsia, and its pharmacological mechanism requires further in-depth study.

Keywords

Mongolian Medicine Danga-5 Tablets; Functional Dyspepsia; Efficacy; Gastrointestinal Function Regulation

References

[1] Wanqing Ch, Rongshou Zh, Peter D Baade, et al. Cancer statistics in China, 2015. CA Cancer J Clin. 2016 Mar-Apr;66(2):115-32. [2] Harriet R, Kevin Sh, Hadrien Charvat, et al.Global burden of cancer in 2020 attributable to alcohol consumption: a population-based study. Lancet Oncol. 2021 Aug;22(8):1071-1080. [3] Yanan Cao, Lin Li, Min Xu, et al.The ChinaMAP analytics of deep whole genome sequences in 10,588 individuals.Cell Res. 2020 Sep;30(9):717-731. [4] Shengsheng Zhang, Luqing Zhao. Consensus Opinion on Traditional Chinese Medicine Diagnosis and Treatment of Functional Dyspepsia. Chinese Journal of Traditional Chinese Medicine,2017,32(6):2595-2598. [5] Zhiming Wang,Liping Wu,Xiaobin Sun. Research progress on the pathogenesis of functional dyspepsia. Journal of Medical Research,2021,50(6):161-164. [6] Eusebi L H, Rabitti S, Artesiani M L, et al. Proton pump inhibitors: Risks of long-term use . J Gastroenterol Hepatol, 2017, 32(7): 1295-1302. [7] Waldum H L, Sørdal Ø, Fossmark R. Proton pump inhibitors (PPIs) may cause gastric cancer-clinical consequences.Scand J Gastroenterol,2018,53(6): 639-642. [8] Xu Z R,Jiang C H,Fan S Y,et al.Comparative pharmacokinetics of naringin and neohesperidin after oral administration of flavonoid glycosides from Aurantii Fructus Immaturus in normal and gastrointestinal motility disorders mice. Chin Herb Med, 2019, 11(3): 314-320. [9] Yulei Liu, Lingyu Zhu.Overview of Traditional Chinese Medicine Treatment for Functional Dyspepsia. Chinese Journal of Integrative Digestive Medicine, 2021, 29(3): 214-217. [10] Lin J, Cai G, Xu J Y. A comparison between Zhishi Xiaopiwan and cisapride in treatment of functional dyspepsia. World J Gastroenterol, 1998, 4(6): 544-547. [11] Ling W,Li Y,Jiang W,et al.Common mechanism of pathogenesis in gastrointestinal diseases implied by consistent efficacy of single Chinese medicine formula: A PRISMA-compliant systematic review and Meta-analysis. Medicine, 2015, 94(27):1111. [12] Zhengxuan Zhang,Xian Li.Mechanism study on the improvement of gastric motility disorders in functional dyspepsia rats by Fructus Aurantii Shaanxi Traditional Chinese Medicine, 2018, 39(8): 998-1000. [13] Xu G L,Xie M,Yang X Y, et al.Spectrum-effect relationships as a systematic approach to traditional Chinese medicine research: Current status and future perspectives. Molecules, 2014, 19(11): 17897-17925. [14] Daoniyaer.Clinical application and experimental research progress of Mongolian medicine Tonglaga-5. Chinese ethnic folk medicine,2014(13):5. [15] Fucheng Bai,Chunying Fu.Research progress on chemical composition and pharmacological activity of Mongolian medicine pomegranate. Frontiers of medicine,2015,5(31):323-324. [16] Shimeny Ramos M, Bruno Ricardo de Castro L- J, Maurilio L-M, et al.In vitro gastrointestinal digestion of a peanut, soybean, guava and beet beverage supplemented with Lactobacillus rhamnosus GG. Food Bioscience.36,100623(2020).