Research Progress on the Mongolian Medicine 'Siwei Tumu Xiang San'

DOI: https://doi.org/10.62517/jmhs.202405312

Author(s)

Xile Mu1, Sirigunqige Pan2,3,*, Minglan Bao2,3,*

Affiliation(s)

1Inner Mongolia University for Nationalities, Tongliao, Inner Mongolia, China 2School of Mongolian Medicine, Inner Mongolia University for Nationalities, Tongliao, Inner Mongolia, China 3Key Laboratory of Mongolian Medicine Research and Development Engineering, Ministry of Education, Tongliao, Inner Mongolia, China *Corresponding Author.

Abstract

This paper investigates the origin, formula analysis, chemical components, pharmacological effects, and clinical applications of the Mongolian medicine 'Siwei Tumu Xiang San,' providing a scientific basis for further research and utilization of this medicine. Through literature review methods, the origin, formula analysis, pharmacological effects, and clinical applications of 'Siwei Tumu Xiang San' are summarized. 'Siwei Tumu Xiang San' originates from "Medical Canon of the Eight Branches" and is a traditional Mongolian medicine formulation. The formula consists of powdered mixtures of Tumu Xiang (200g), Bitter Ginseng (200g), Climbing Raspberry (100g), and Galangal (50g). Clinically, it is used to treat early-stage febrile diseases characterized by chills, fever, headache, cough, sore throat, and chest and hypochondriac pain. 'Siwei Tumu Xiang San' has shown significant efficacy in treating febrile diseases and is worthy of further exploration and research.

Keywords

Siwei Tumu Xiang San; Formula Origin Investigation; Formula Analysis; Chemical Components; Pharmacological Effects; Clinical Applications

References

[1] Pharmacopoeia Commission of the People's Republic of China. Pharmacopoeia of the People's Republic of China: Volume 1. Beijing: China Medical Science Press, 2010: 647—648. [2] Inner Mongolia Health Department. Standards of Inner Mongolia Mongolian Medicines. Chifeng: Inner Mongolia Science and Technology Press, 1984: 337. [3] Zhanbuladaoji. The Unerring Mongolian Medicine Identification. Chifeng: Inner Mongolia Science and Technology Press, 1988: 254. [4] Luobsang. The Complete Works of Mongolian Medicine by Mongolian Medical Scholar Luobsang: Mongolian Materia Medica. Chifeng: Inner Mongolia Science and Technology Press, 2011: 1831 - 1848. [5] Bohlmann F, et al. Phytochemistry. 1978, 17(7): 1165. [6] Xiaojun Zhang, Sunwanqi Yu. Research progress on the chemical components and pharmacological effects of Bitter Ginseng. Traditional Chinese Medicine Information, 2023, 40(12): 79-87. [7] Yin Jian, et al. Modern Research and Clinical Application of Traditional Chinese Medicine. Beijing: Xueyuan Press, 1993: 424. [8] Yanli Wang, Yue Xin, Xuefei Bai, et al. Research progress on the Mongolian medicinal herb Climbing Raspberry. Asia-Pacific Traditional Medicine, 2018, 14(12): 29-33. [9] Luobuzengsule and Mu. Materia Medica. Beijing: Ethnic Publishing House, 1998: 310. [10] Yanfang Liu, Pinkang Wei. Effects of volatile oil extracts of Galangal on human gastric cancer tissue in nude mice. Journal of Clinical Oncology, 2005, (05): 486-488+491. [11] Yishibalazhuur. The Unerring White Crystal Identification of Medicines. Chifeng: Inner Mongolia People's Publishing House, 1998: 127. [12] Yimi Dafu. Chemical Components of Plants (Japan) (Revised 6th Edition), 1960: 192. [13] Xiaona Li, Xin Dong,Na Li, et al. Rapid analysis and identification of the chemical components of Siwei Tumu Xiang San by HPLC-Q-Exactive-MS/MS high-resolution mass spectrometry. Chinese Journal of Experimental Traditional Formulae, 2020, 26(6): 121—131. [14] Gao X, Ma Y, Wang Z, et al. Identification of anti-inflammatory active ingredients from Inulin by ultra-performance liquid chromatography/quadrupole time-of-flight-MSE. Biomed Chromatogr, 2018, 32(5): e4179. [15] Liu G, Dong J, WANG H, et al. Characterization of alkaloids in Sophora flavescens Ait. by high-performance liquid chromatography-electrospray ionization tandem mass spectrometry. J Pharmaceut Biomed Anal, 2011, 54(5): 1065—1072. [16] Qinqin Zhao, Yufeng Zhang, Xiaohui Fan, et al. Simultaneous identification of two major active components in Bitter Ginseng using HPLC-MS/MS. China Journal of Chinese Materia Medica, 2011, 36(6): 762—769. [17] Zhang L, Xu L, Xiao S S, et al. Characterization of flavonoids in the extract of Sophora flavescens Ait. by high-performance liquid chromatography coupled with diode-array detector and electrospray ionization mass spectrometry. J Pharmaceut Biomed Anal, 2007, 44(5): 1019—1028. [18] Zhang Y, Zhang P, Cheng Y, et al. Structural characterization of isoprenylated flavonoids from Kushen by electrospray ionization multistage tandem mass spectrometry. J Mass Spectrometry, 2008, 43(10): 1421—1431. [19] Weng Z, Zeng F, Zhu Z, et al. Comparative analysis of sixteen flavonoids from different parts of Sophora flavescens Ait. by ultra high-performance liquid chromatography-tandem mass spectrometry. J Pharmaceut Biomed Anal, 2018, 156: 214—220. [20] Xiaona Li, Xin Dong, Baoquan Bao, et al. Rapid analysis and identification of chemical components in the Mongolian and Chinese medicinal herb Bitter Ginseng using Q-Exactive high-resolution mass spectrometry. Chinese Medicinal Materials, 2002, 42(1): 103-109. [21] Chang J, Lane M, Yang M, et al. A hexa-herbal TCM decoction used to treat skin inflammation: an LC-MS-based phytochemical analysis. Planta Med, 2016, 82(11/12): 1134—1141. [22] Shangzhi Ma, Huiyu Qin, Fei Long, et al. Identification of gallic polyphenolic compounds and their fragmentation patterns in UPLC-MS/MS. Chinese Herbal Medicine, 2017, 48(22): 4632—4638. [23] Guodong Sun, Jinhai Huo,Tuan Cheng, et al. Chemical component analysis of walnut leaf based on UPLC-Q-TOF/MS technology. Chinese Medicinal Materials, 2017, 40(5): 1123—1129. [24] Guodong Sun, Jinhai Huo, Gaili Wang, et al. Analysis of components in walnut bark based on UPLC-Q-TOF/MS technology. Chinese Herbal Medicine, 2017, 48(4): 657—667. [25] Gegentana. Study on the active components of the Mongolian medicinal herb Climbing Raspberry—Research on the active components of the ethyl acetate layer and n-butanol layer. Tongliao: Inner Mongolia University for Nationalities, 2012. [26] Zhonghua Zhao, Xiulan Wang, Yuying Wang, et al. The analgesic and anti-inflammatory effects of Siwei Tumu Xiang San. Chinese Journal of Ethnomedicine and Ethnopharmacy, 1996, 5(Supplement): 105—107. [27] Hui Li. Study on the immunomodulatory activity of the Mongolian medicine Chagan Soup. Hohhot: Inner Mongolia Medical University, 2020. [28] Surina. Study on the effects of Chagan Soup on the urinary metabolomics of model rats with immature heat syndrome. Inner Mongolia University for Nationalities, 2023. [29] Bihui Jiang, Minghui Wei, Ziyu Lu, et al. Exploration of the protective mechanism of Mongolian medicine Siwei Tumu Xiang San on pressure overload-induced myocardial hypertrophy in rats based on the miR-34a-5p/Notch1 signaling pathway. Journal of Inner Mongolia Medical University, 2023, 45(02): 129-133+139. [30] Surongzhabu. Mongolian Internal Medicine. Hohhot: Inner Mongolia People's Publishing House, 1989: 105. [31] Burindalai. Mongolian Febrile Diseases. Hohhot: Inner Mongolia Education Press, 2006: 57. [32] Ulantuya, Sumuya, Baolechaolu. Evaluation of the efficacy of Mongolian medicine in the treatment of influenza. World Clinical Drugs, 2014, 10: 626—628. [33] Chunlei Ma, Lijuan Wang. A brief discussion on the clinical application of Siwei Tumu Xiang San. Chinese Journal of Ethnomedicine and Ethnopharmacy, 2012, 18(3): 59—60. [34] Burindalai, Siriguleng, Jiren Huang, et al. Analysis of the efficacy of Mongolian medicine in treating viral hepatitis. Journal of Chinese Ethnic Folk Medicine, 2003(2): 90—92. [35] Gaowa. Mongolian medicine in the treatment of asthma. Chinese Journal of Ethnomedicine and Ethnopharmacy, 2005(2): 11. [36] Genxiao Sun, Wuningjirigala, Qiwen. Observation of the efficacy of Mongolian medicine in treating inflammatory bowel disease. Chinese Journal of Ethnomedicine and Ethnopharmacy, 2006(06): 22-23.