Methods of Preparation of Cellular Wax Blocks for Plasmapheresis and Their Diagnostic Evaluation

DOI: https://doi.org/10.62517/jmhs.202405418

Author(s)

Chen Junlin1, Li Yue2,*, Jiang Can3

Affiliation(s)

1Pathology of Department, Hubei Provincial Hospital of TCM, Wuhan, China 2Pathology of Department, Shizhu Tujia Autonomous County People’s Hospital, Chongqing, China 3Pathology of Department, Hubei Provincial Hospital of TCM, Wuhan, China *Corresponding author

Abstract

Plasmapheresis specimens, which are commonly utilized in clinical laboratory diagnostics, contain crucial information for the diagnosis of numerous medical conditions. This article delves into the preparation and diagnostic evaluation of cellular wax blocks derived from plasmapheresis, with a focus on their application in clinical pathology and cytology. Utilizing techniques such as centrifugation and fixation, cellular components are extracted, preserved, and processed for histopathological examination. Immunohistochemistry and molecular diagnostics further enhance diagnostic accuracy, guiding personalized treatment strategies. Despite their advantages, challenges such as contamination and variability in block quality persist. This article presents a comprehensive analysis of cellular wax block techniques, including preparation methods, clinical case studies, and diagnostic interpretation. Moving forward, standardization and refinement of these techniques are essential to optimize diagnostic accuracy and reproducibility, ultimately improving patient outcomes in pathology.

Keywords

Plasmapheresis; Cellular Wax Blocks; Histopathology; Immunohistochemistry; Cytology; Diagnostic Evaluation

References

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