Application Effect of Linaclotide Combined with Polyethylene Glycol Dissolved in 1l Pulse Beverage in Bowel Preparation for Colonoscopy

DOI: https://doi.org/10.62517/jmhs.202505116

Author(s)

Shen Yang, Jiang Xing, Luo Rui

Affiliation(s)

Department of Gastroenterology, People’s hospital of Deyang City, Deyang, China

Abstract

Colorectal cancer is a global health threat, and colonoscopy is crucial for early diagnosis. Traditional 2L or 3L polyethylene glycol (PEG) for bowel preparation has issues with patient tolerance. This randomized, endoscopist - blinded, single - center study compared 1L PEG + 580μg linaclotide (1L PEG + L group) and 2L PEG alone in 993 patients scheduled for colonoscopy. There were no significant differences in Boston Bowel Preparation Scale (BBPS) scores, polyp detection rate, or adenoma detection rate between the two groups (P>0.05). However, the incidence of adverse events was 8.87% in the 1L PEG + L group and 33.88% in the 2L PEG group (P<0.05). The 1L PEG + L group is non - inferior to the 2L PEG group in bowel preparation for colonoscopy, with a lower adverse event rate, suggesting a good application prospect.

Keywords

Linaclotide; Polyethylene Glycol; Bowel Preparation; Colonoscopy; Adverse Events

References

[1]Park B S ,Lee M ,Kwak S M , et al. Acute Gastropathy Associated with Bowel Preparation for Colonoscopy. [J]. The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi, 2024, 84 (2): 82-89. [2]Chen S ,Zhang T ,Zhu S , et al. A study on the related influencing factors of the quality of bowel preparation and the compliance of middle-aged and elderly patients for colonoscopy. [J]. Current medical research and opinion, 2024, 11-17. [3]Online Educational Module Improves Knowledge of Nurses on Bowel Preparation for Colonoscopy. [J]. Gastroenterology nursing : the official journal of the Society of Gastroenterology Nurses and Associates, 2024, 47 (4): 11-14. [4]Kim G ,Lee H W ,Kang S , et al. Vomiting-induced pharyngeal perforation during bowel preparation for colonoscopy: A case report. [J]. World journal of clinical cases, 2024, 12 (18): 3615-3621. [5]Maida M ,Vitello A ,Zullo A , et al. Gender Differences in Quality of Bowel Preparation for Colonoscopy: Post Hoc Analysis of a Randomized Controlled Trial. [J]. Journal of clinical gastroenterology, 2024,11(1):10-23. [6]Kim SY,Kim HS,Park HJ.Adverse events related to clonoscopy:Global trends and future challenges[J].World J Gastroenterol,2019,25(2):190-2-4. [7]Aragona E S ,Spada C ,Luca D L , et al. Probiotics for managing patients after bowel preparation for colonoscopy: an interventional, double-arm, open, randomized, multi-center, and national study (COLONSTUDY). [J]. Minerva gastroenterology, 2024, 70 (2): 187-196. [8] Bassotti G,Usai-Satta P,Bellini M.Linaclotide for the treatment of chronic constipation[J].Expert Opin Pharmacother,2018,19(11):1261-1266. [9]Love BL,Johnson A,Smith LS.Linaclotide:a novel agent for chronic constipation and irritable bowel syndrome[J].Am J Health Syst Pharm,2014,71(13):1081-1091. [10]Zhang M, Zou W, Xu C, et al. Polyethylene glycol combined with lina- clotide is an effective and well-tolerated bowel preparation regimen for colonoscopy: an endoscopist-blinded, randomized, controlled trial. Eur J Gastroenterol Hepatol 2021;33:e625-33. [11]Stein DJ,Copland A,McDaniel D,et al. Single-dose linaclotide is equal in efficacy to polyethylene glycol for bowel prepatation pror to capsule endoscopy.[J].Dig.Dis (Basel,Switzerland).2019,37(4):297-302. [12]Chen Z,Xia C,Bin T,et al.A novel ultra-low-volume regimen combining 1 L polyethylene glycol and linaclotide versus 2 L polyethylene glycol for colonoscopy cleansing in low-risk individuals: a randomized controlled trial.Gastrointestinal Endoscopy.2023,97(5):952-961. [13]Alomar T ,Choe S ,Boddupalli D . Hyponatremia After Colonoscopy Bowel Preparation: Challenges in Managing Syndrome of Inappropriate Antidiuretic Hormone Without Established Guidelines. [J]. Cureus, 2024, 16 (6): e61960. [14]Spada C, Mcnamara D, Despott E J, et al. Performance measures for small-bowel endoscopy: a European Society of Gastrointestinal Endoscopy (ESGE) quality improvement initiative[J]. Endoscopy, 2019, 7(5): 614-641. [15]Damjanovska S ,Watanabe S ,Karb B D , et al. Improving Inpatient Colonoscopy Bowel Preparation: A Successful Quality Improvement Project. [J]. American journal of medical quality : the official journal of the American College of Medical Quality, 2024