STEMM Institute Press
Science, Technology, Engineering, Management and Medicine
Progress in the Study of C5a and Coronary Heart Disease
DOI: https://doi.org/10.62517/jmhs.202505216
Author(s)
Yang Yang, Zhang Zhen*
Affiliation(s)
Hunan Normal University Affiliated Xiangdong Hospital, Zhuzhou , Hunan, China *Corresponding Author
Abstract
This article reviews recent research progress on C5a and coronary heart disease and discusses its potential mechanisms and clinical applications in disease onset and progression. First, C5a is a highly active complement component that plays an important role in immune and inflammatory responses. In recent years, more and more studies have focused on its role in coronary heart disease. Its mechanism consists of three main aspects: inflammatory response, thrombosis and atherosclerosis.C5a exacerbates the formation and rupture of atherosclerotic plaques by activating the inflammatory pathway, promoting cytokine secretion and inflammatory cell infiltration. It also enhances platelet aggregation and coagulation factor release, thereby promoting thrombosis. Clinical studies have further validated the importance of C5a in patients with coronary artery disease and found that it may not only serve as a biomarker for cardiovascular risk prediction, but also has potential clinical diagnostic and prognostic value. In terms of treatment, clinical intervention strategies for C5a need to be further validated for safety and efficacy. In summary, the role of C5a in the development of coronary heart disease and its potential as a therapeutic target are receiving increasing attention. Future research will focus on further revealing its specific mechanism of action and optimizing the clinical application of the blocker. This not only has the potential to improve the therapeutic efficacy of coronary artery disease, but will also promote the development of complement system-related research. With the deeper understanding of C5a function and the promotion of blockers, it is expected that this target will play an increasingly important role in coronary heart disease treatment.
Keywords
C5a; Coronary Heart Disease; Inflammatory Response; Atherosclerosis; Thrombosis
References
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