Pre-Gastroscopic Postural Intervention Combined with Mucosal Cleansing Agents: A Narrative Review

DOI: https://doi.org/10.62517/jmhs.202505416

Author(s)

Kun Ma, Zhiyong Pang*

Affiliation(s)

Digestive Endoscopy Center, Hohhot First Hospital, Hohhot, Inner Mongolia, China *Corresponding Author

Abstract

Gastroscopy remains the cornerstone for the diagnosis and therapeutic management of upper-gastrointestinal disorders and constitutes the principal modality for detecting gastric cancer and its premalignant lesions. Early detection is pivotal to improving survival. Intragastric foam and mucus consistently impair endoscopic visualisation, constituting a primary source of missed or delayed diagnosis of early gastric cancer and other mucosal lesions and thereby reducing the detection rate of clinically significant pathology. Residual bubbles and viscous secretions adhering to the gastric surface are the principal optical barriers encountered during routine gastroscopy. Adequate mucosal preparation that effectively eliminates these contaminants is therefore essential for maximising lesion detection. The combined administration of dimethicone powder and Pronase Granules has been shown to exert potent defoaming and mucolytic activity and is explicitly recommended in recent Chinese guidelines for digestive endoscopy as the preferred pre-procedural regimen for optimising gastric surface cleanliness. An unobstructed endoscopic view is therefore mandatory, particularly for the recognition of early gastric cancer. Accumulating evidence indicates that the combined administration of dimethicone powder and Pronase Granules, augmented by sequential postural manoeuvres, is emerging as a standard pre-treatment protocol for optimising gastric mucosal cleanliness. Systematic postural manoeuvres enable the dimethicone–pronase mixture to coat the entire gastric cavity uniformly, thereby enhancing mucosal cleanliness, shortening procedure time, and increasing the detection rate of early gastric cancer.

Keywords

Gastroscopy; Dimethicone; Pronase Granules; Postural Intervention

References

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