Application of Auricular Acupoint Pressing Combined With Zusanli Acupoint Injection of Vitamin B1 in Patients with Breast Cancer Undergoing Chemotherapy

DOI: https://doi.org/10.62517/jmhs.202605120

Author(s)

Yanrong Yu, Shufang Deng, Hao Peng, Keneng Deng, Dalang Fang*

Affiliation(s)

Department of Gland Surgery, Affiliated Hospital of Youjiang Medical University for Nationalities, Key Laboratory of Tumor Molecular Pathology of Baise, Baise, Guangxi, China *Corresponding Author

Abstract

This study evaluated the clinical efficacy of auricular acupoint pressing combined with Zusanli acupoint injection of vitamin B1 for preventing chemotherapy-induced nausea and vomiting (CINV) in patients with breast cancer. A total of 120 patients receiving highly emetogenic chemotherapy were randomly assigned to four groups (n=30 each). Group A received a standard antiemetic regimen consisting of a 5-HT3 receptor antagonist and dexamethasone. Group B received additional auricular acupoint pressing, group C received Zusanli acupoint injection of vitamin B1, and group D received both interventions in addition to the standard regimen. Baseline characteristics were comparable among the four groups. The severity of nausea and vomiting was evaluated at multiple time points, while quality of life and physical status were assessed using the Karnofsky Performance Status (KPS) and Zubrod Performance Status scores. Significant differences in nausea severity were observed among the groups at all observation time points, and vomiting severity also differed significantly at most time points. The combined intervention group showed the most effective control of both symptoms. In addition, cumulative KPS and Zubrod scores differed significantly among the groups. Patients receiving the combined intervention demonstrated higher KPS scores and lower Zubrod scores, indicating improved functional status and treatment tolerance. Only mild adverse events were reported, and no treatment discontinuation occurred. Auricular acupoint pressing combined with Zusanli acupoint injection of vitamin B1, when added to standard antiemetic therapy, may synergistically improve the control of CINV and enhance quality of life and physical performance in patients with breast cancer.

Keywords

Breast Cancer; Chemotherapy; Nausea and Vomiting; Auricular Acupoint Pressing; Zusanli; Vitamin B1

References

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