Observation of Effect of Silk Fibroin Composite Gel for Repair of Facial Contusion Wound and Skin Barrier Function

DOI: https://doi.org/10.62517/jmhs.202605221

Author(s)

Cai Weiwei, Hu Dong, Huang Boping, Hong Zhendong*

Affiliation(s)

Guangxi Guilin Lingchuan People's Hospital, Guilin, China *Corresponding Author

Abstract

This study aims to observe the clinical effect of silk fibroin composite gel and silk fibroin patch on the wound repair and skin barrier function of facial contusions. A total of 123 patients with facial contusions were selected and randomly divided into a composite gel group (n=41), a patch group (n=41), and a control group (n=41). The composite gel group used silk fibroin composite gel (Siruimei Biotechnology). The patch group used silk fibroin medical patch (Fangchenggang Ruiyi Biotechnology). The control group used recombinant human epidermal growth factor (rhEGF) gel. The clinical effect, wound repair time, skin barrier function, and adverse reactions were compared among the three groups. The results showed that the total effective rate of the composite gel group was 95.12%, which was significantly higher than 90.24% of the patch group and 80.48% of the control group (P<0.05). The pain relief time (5.28±0.78 hours) and wound healing time (4.58±1.65 days) in the composite gel group were significantly shorter than those in the other two groups (P<0.05). After treatment, the sebum content (102.04±16.47 μg/cm²) and stratum corneum hydration (25.25±4.12%) in the composite gel group were significantly higher than those in the control group (P<0.05). The incidence of adverse reactions in the composite gel group was 4.88%, which was significantly lower than 17.07% in the control group (x2= 7.521, P<0.05). In conclusion, silk fibroin composite gel has a very good clinical effect on facial contusions. It can relieve pain quickly, speed up wound healing, and effectively repair the skin barrier safely.

Keywords

Silk Fibroin Composite Gel; Silk Fibroin Patch; Facial Contusion; Wound Repair; Skin Barrier Function

References

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