Progress in the Study of Chemical Composition and Pharmacological Effects of Dipsaci Radix and Predictive Analysis of Quality Markers

DOI: https://doi.org/10.62517/jmhs.202605223

Author(s)

Jinfei He1, Qingmei Deng2, Chunyuan Gou2, Xinlin Gao1, Liting Qing2, Junfeng Su1, Yaohua Li2,*

Affiliation(s)

1Faculty of Chinese Medicine Science Guangxi University of Chinese Medicine, Nanning, Guangxi, China 2National Demonstration Center for Experimental Chinese Medicine Education (Guangxi University of Chinese Medicine), Nanning, Guangxi, China *Corresponding Author

Abstract

Dipsaci Radix, the dried root of Dipsacus asper Wall. ex Henry, is a traditional Chinese medicinal herb. Modern phytochemical research indicates that it predominantly contains triterpenoid saponins, iridoids, volatile oils, alkaloids, lignans, polysaccharides, and other chemical components. Clinically, it is widely used to treat conditions associated with liver and kidney deficiency, such as soreness and weakness of the lower back and knees, rheumatic arthralgia, traumatic injuries, bone fractures, metrorrhagia, and threatened miscarriage. This study presents a predictive analysis of potential quality markers (Q-Markers) for Dipsaci Radix based on multiple perspectives, including its botanical phylogenetic relationships, the measurability of its chemical components, its traditional properties according to Chinese medicine, the effects of different processing methods, and its geographical origins. The analysis has identified the following compounds as potential Q-Markers: asperosaponin VI, loganin, loganic acid, sylvestroside I, dipsanoside B, dipsanoside A, sweroside, asperosaponin X, asperosaponin XIII, α-hederin, 5-hydroxymethylfurfural (5-HMF), isochlorogenic acid A, chlorogenic acid, isochlorogenic acid B, isochlorogenic acid C, caffeic acid, ursolic acid, and hederagenin. This study provides a scientific reference for Q-Marker research and the refinement of the quality evaluation system for Dipsaci Radix.

Keywords

Dipsaci Radix; Chemical Composition; Pharmacological Action; Quality Marker

References

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