Study on the Regulatory Mechanism of the Gs Protein Signaling Pathway in Diabetic Retinopathy

DOI: https://doi.org/10.62517/jmhs.202605308

Author(s)

Moyang Hao

Affiliation(s)

School of Medicine, Shanxi Datong University, Datong, Shanxi, China

Abstract

Diabetic retinopathy is one of the microvascular complication induced by primary diabetes, characterized by neurovascular unit damage and blood-retinal barrier (BRB) breakdown. It causes visual impairment of varying severity, ranging from mild vision loss to complete blindness. Although the Gs pathway is not the core pathway in DR pathogenesis, it contributes to DR progression and holds important research significance. The Gs protein pathway mainly regulates physiological processes including cell proliferation, differentiation, and homeostasis maintenance through the Gs-cAMP-PKA signaling cascade. In addition, the Gs pathway is essential for the regulation of inflammatory responses and oxidative stress. The present study is based on the rationale that a persistent hyperglycemic environment caused by primary diabetes suppresses the Gs pathway, leading to dysfunction of its downstream regulated processes and the occurrence of secondary disorders such as DR. By elaborating the pathogenesis of DR in detail, this review aims to identify current research gaps, clarify the potential value of this pathway in DR treatment and drug development, and promote the translation of basic research into clinical applications.

Keywords

Diabetic Retinopathy; Gs Protein pathway; Oxidative Stress; Inflammation; Regulatory Mechanism

References

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