Reconstruction of Urban Health Policy Driven by Epigenetic Early Warning

DOI: https://doi.org/10.62517/jsse.202508204

Author(s)

Zhirui Wu*

Affiliation(s)

Global Health Research Center, Duke Kunshan University, Kunshan, Jiangsu, China *Corresponding Author

Abstract

This paper explores the epigenetic impact of PM2.5 and heavy metal pollution on hypomethylation of peripheral blood LINE-1 during rapid urbanization in developing countries and its association with senile neurodegenerative diseases. The study proposes a shift from traditional disease treatment to an early warning system based on epigenetic dose-effect, integrating environmental engineering and molecular biology technologies to construct a dynamic monitoring network. Aiming at resource constraints, a three-tier policy framework of "low-cost screening-targeted governance-personalized intervention" is designed to achieve visual monitoring of environmental health risks for the elderly in communities. Through systems biology modeling and machine learning analysis of multi-omics data, a quantitative relationship among environmental exposure-epigenetics-disease risk is established, providing a scientific basis for precise public health intervention.

Keywords

Epigenetics; Urban Health; Public Health Policy; Environmental Epigenomics

References

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